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Table 1 Data on the groups used for the simulations. The results are given as the mean (SD)

From: How fast can glucose be infused in the perioperative setting?

Study group

Experiments (N)

Age (years)

Body weight (kg)

Female/males

Glucose load (g/kg)

Plasma glucose baseline (mmol/l)

Plasma insulin baseline (pmol/l)

10log HOMA-IRa

V d/BW (ml/kg)

CL/BW (ml/(kg min))

Half-lifeb (min)

Reference

Healthy volunteers

44

29 (7)

73 (14)

8/18c

0.25–0.62

5.0 (0.4)

35 (23)

2.15 (0.33)

164 (74)

8.7 (3.4)

15 (8)

Sjöstrand and Hahn (2003); Hahn et al. (2011)

1 day before hip replacement surgery

82

68 (9)

82 (15)

54/28

0.20–0.30

5.2 (0.7)

62 (50)

2.38 (0.35)

164 (29)

4.7 (1.8)

28 (11)

Hahn et al. (2013); Ljunggren and Hahn (2012)

During hernia surgery

9

37 (16)

80 (11)

0/9

≈0.20

5.7 (0.4)

152 (24)

1.6 (0.3)

66 (13)

Sicardi Salomón et al. (2006)d

During laparoscopic cholecystectomy

20

40 (8)

75 (10)

14/6

0.25–0.47

5.0 (0.6)

45 (26)

2.29 (0.25)

121 (19)

2.8 (0.7)

33 (12)

Sjöstrand and Hahn (2004); Sicardi Salomón et al. (2006)d

During open abdominal surgery

9

69 (6)

63 (11)

4/5

≈0.20

5.7 (1.1)

190 (34)

1.5 (0.7)

110 (67)

Sicardi Salomón et al. (2006)d

2–3 h after hip replacement surgery

60

68 (9)

83 (15)

41/9

0.20

5.9 (1.1)

47 (28)

2.35 (0.34)

174 (34)

3.3 (0.9)

38 (11)

Ljunggren and Hahn (2012)

1 day after hip replacement surgery

82

68 (9)

82 (15)

41/19

0.20–0.30

6.3 (0.8)

66 (44)

2.55 (0.27)

170 (31)

3.7 (1.3)

35 (13)

Hahn et al. (2013); Ljunggren and Hahn (2012)

2 days after hysterectomy

15

50 (5)

70 (9)

15/0

0.31

6.2 (0.7)

35 (16)

2.28 (0.25)

147 (41)

6.1 (1.2)

17 (5)

Strandberg and Hahn (2005)

  1. aThe 10log of (P-glucose × P-insulin). For crude HOMA-IR, the product should be divided by 156 to correct for units (22.5 if insulin is reported in mU l−1) where 1 = normal
  2. bThe half-life was obtained as 0.693 V d/CL
  3. cSix males underwent four experiments each
  4. dThe study divided the kinetics into infusion and postinfusion phase. The kinetics from the infusion was used here