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Table 1 Baseline and intraoperative characteristics

From: The effect of goal-directed crystalloid versus colloid administration on postoperative spirometry parameters: a substudy of a randomized controlled clinical trial

Factors and variables

Crystalloid (n = 31)

Colloid (n = 29)

p-value

ASD

Age; yrs

52 ± 13

53 ± 17

 

0.06

Height; cm

172 ± 8

171 ± 9

 

0.01

1

Weight; kg

75 ± 11

77 ± 21

 

0.15

BMI; kg/m2

25 ± 4

26 ± 5

16/13

 

0.11

Sex (m/f); n

18/13

 

0.06

ASA score (1/2/3); n

11/17/3

7/16/6

 

0.34

Smoking history (yes/no); n

8/23

6/23

 

0.12

Type of surgery (upper abdominal/colorectal); n

21/10

21/8

 

0.10

 Liver resection; n

9

18

  

 Pancreaticoduodenectomy; n

8

1

  

 Rectal surgery; n

6

6

  

 Colectomy; n

3

1

  

 Left pancreatectomy; n

2

2

  

 Sigma resection; n

1

1

  

 Total pancreatectomy; n

1

0

  

 Sarcoma resection; n

1

0

  

Duration of surgery; min

267 ± 106

228 ± 92

 

0.39

Intraoperative variables

    

 TWA MAP; mmHg

71 ± 8

78 ± 9

0.51a

 

 TWA HR; bpm

70 ± 12

72 ± 12

0.78a

 

 TWA CVP; mmHg

8 ± 2

10 ± 3

0.14a

 

 TWA FTc; msec

353 ± 22

359 ± 21

0.45a

 

 TWA SV; ml

78 ± 17

80 ± 16

0.99a

 

TWA end-tidal sevoflurane; %

2 (1.8–2.1)

1.8 (1.7–2)

0.02b

 

Fentanyl, μg

1006 ± 423

847 ± 353

0.63a

 

Total fluid intake; mlc

4567 (3500–5800)

3044 (2125–3825)

0.01b

 

Crystalloids; ml

4100 (3025–5041)

1300 (955–2000)

< 0.001b

 

Colloids; ml

N.a.

1250 (750–1500)

N.a.

 

Number of boluses; n

9 (6–12)

5 (3–6)

< 0.001b

 

Vasopressor therapy (yes/no); n

23/8

13/16

0.03d

 

Phenylephrine; mg

0.32 (0.14–0.8)

0.29 (0.18–0.56)

1.00b

 

Norepinephrine; mg

0.1 (0.06–0.12)

0.02

1.00b

 

Urinary output; ml

300 (200–450)

300 (135–475)

0.83b

 

Blood loss; ml

400 (175–600)

300 (150–1000)

0.59b

 

TWA BE; mmol/l

−1.9 ± 1.9

−2.1 ± 2

0.63a

 

TWA FiO2, %

79 (78–80)

79 (77–80)

0.94b

 

PaO2 (start of surgery); mmHg

366 (324–453)

400 (305–458)

0.30b

 

 PaO2/FiO2 ratio; mmHg

454 (385–480)

453 (383–516)

0.70b

 

PaO2 (end of surgery); mmHg

381 (326–429)

392 (359–428)

0.80b

 

 PaO2/FiO2 ratio; mmHg

462 (404–500)

488 (443–526)

0.37b

 

PaCO2; mmHg

40 ± 3

41 ± 3

0.55a

 
  1. Data are presented as mean ± SD, median (IQR), or number. Abbreviations: ASA American Society of Anesthesiologists, ASD absolute standardized differences, BMI body mass index, CVP central venous pressure, f female, FiO2 fraction of inspired oxygen concentration. FTc corrected flow time, HR heart rate, m male, MAP mean arterial pressure, PaCO2 arterial partial pressure of carbon dioxide, PaO2 arterial partial pressure of oxygen, SV stroke volume, TWA time-weighted average. aUnpaired, two-tailed t-test. bWilcoxon rank-sum test. cTotal fluid intake includes baseline, fluid boli, antibiotics, analgesics, and additional fluid, administered at the discretion of attending anesthesiologist. dFisher’s exact test
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Perioperative Medicine

ISSN: 2047-0525