Table 1 Studies included in the meta-analysis
Year | Author | Jadad score | Type of study | Sample size | Application of TXA | Dose of TXA | Methods | Results |
|---|---|---|---|---|---|---|---|---|
Breast surgery | ||||||||
2023 | Safran et al. (Safran et al. 2023) | 5 | RCT | 82 | Topical | 3.0 g | TXA vs. placebo | Decrease in drain output in mastectomy |
2023 | Yao et al. (Yao et al. 2023) | 5 | RCT | 98 | Topical | 1.0 g | TXA vs. placebo | TXA did not decrease the incidence of haematoma and in drainage output |
2020 | Ausen et al. (Ausen et al. 2020) | 5 | RCT | 202 | Topical | 0.5 g | TXA vs. placebo | TXA reduce the blood loss |
Liposuction | ||||||||
2023 | El Minawi et al. (Minawi et al. 2023) | 5 | RCT | 90 | Topical and systematic | 8 mg/kg | TXA topical vs. TXA systemic vs. placebo | TXA reduced the blood loss |
2022 | Hayo et al. (Hoyos et al. 2022) ha | 5 | RCT | 141 | Topical and systematic | 1.0 g | TXA topical vs. TXA systemic vs. placebo | TXA groups had higher haemoglobin levels |
Rhinoplasty | ||||||||
2017 | Ghavimi et al. (Ghavimi et al. 2017) | 5 | RCT | 50 | Systemic | 10 mg/kg | TXA vs. placebo | Decrease intraoperative bleeding |
2016 | Eftekharian et al. (Eftekharian and Rajabzadeh 2016) | 5 | RCT | 50 | Systemic | 1.0 g | TXA vs placebo | Decrease intraoperative bleeding |
2015 | Beikaei et al. (Beikaei et al. 2015) | 5 | RCT | 100 | Systemic | 10 mg/kg | TXA vs placebo | Decrease intraoperative bleeding |
2022 | Habibi et al. (Habibi et al. 2022) | 5 | RCT | 198 | Topical | 5 mg/kg | TXA vs placebo | Decrease intraoperative bleeding |
2021 | Avci et al. (Avci 2021) | 5 | RCT | 90 | Systemic | 1 g | TXA vs placebo | Decrease intraoperative bleeding |