A systematic review and meta-analysis of systematic and topical tranexamic acid administration in aesthetic plastic surgery

Table 2LE: Table 3 has been renumbered to Table 2 including its citation. Please check if the action taken is appropriate and amend if necessary. The GRADE evidence

No. of studies	Study design	Quality assessment					No. of patients		Effect	Quality
No. of studies	Study design	Risk of bias	Inconsistency	Indirectness	Imprecision	Other	Adjuvant	Control	Absolute (95% Cl)	Quality
Total blood loss — systemic TXA
5	RCT	Not serious	Serious^a	Not serious	Not serious	No	165	165	MD − 18.05 (− 22.01; − 14.09)	+ + + Moderate
Total blood loss — topical TXA
2	RCT	Not serious	Serious^b	Not serious	Not serious	No	129	129	MD − 74.93 (− 88.79; − 61.07)	+ + + Moderate
Drainage output — topical TXA
2	RCT	Not serious	Not serious	Not serious	Not serious	No	199	199	MD 33.53 (14.29; 52.77)	+ + + + High
Haematoma –– topical TXA
4	RCT	Not serious	Not serious	Not serious	Not serious	No	259	256	MD 0.30 (0.07, 1.25)	+ + + + High

RCT randomised controlled trial, Cl confidence interval, PNB peripheral nerve block, MD mean difference. ^aHeterogeneity: I² = 69%. ^bHeterogeneity: I² = 67%

ISSN: 2047-0525