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Table 2 Patient characteristics and technical aspects of surgery

From: Hemolysis during open heart surgery in patients with hereditary spherocytosis — systematic review of the literature and case study

 

Author

Year

Age

Gender

Past medical history

Splene-ctomy

Surgery

CPB

CPB priming

Temperature °C

Cardioplegia

Xclamp (min)

CPB (min)

Total blood loss (hospital)

Blood

Additional treatment

LOS

Complicatons

Hemolysis

1

Moyes

1971

16

F

-

Yes

MVpl

Short occusive

Ringer’s solution

-

-

-

-

-

-

-

21

No

No

2

Moyes

1974

5

M

Fallot’s tetralogy

No

VSD clousure,

RV infundibiulectomy

Temptrol oxygenator

Ringer’s solution, donors blood

-

-

-

-

-

-

-

20

-

Yes

3

deLeval

1974

-

F

-

Yes

MVR, TVR (mech)

-

-

-

-

-

100

-

-

-

-

No

No

4

Chun

1982

38

F

-

Yes

MVR (mech 25 mm)

TVR (mech 29 mm)

AVR (mech 21 mm)

-

-

-

-

59

189

-

-

-

-

-

No

5

Gayyed

1993

67

M

HSM

No

AVR (bio 25 mm)

-

-

28

-

-

68

1050

RBC

-

-

Hemolysis

Yes

6

Gayyed

1993

60

F

HF, HSM

No

MVR (bio 33 mm)

-

Packed RBCs

24

-

-

80

400

RBC

-

14

No

-

7

Gayyed

1993

64

M

IHD

Ye

VSD clousure

-

-

24

-

-

110

1950

RBC

-

21

Total parenteral nutrition, renal failure

-

8

Aykac

1994

15

F

-

Yes

MVpl

Roller pump,

bubble oxygenator

Total exchange transfusion

Hypotheria

Cold, crystalloid

-

-

-

RBC

-

-

-

No

9

Kawahira

1994

15 months

M

Chomosome 8 defect

No

PDA closure, MVpl, LA plication

-

Poloxamer 188

-

-

55

180

127

RBC

Haptoglobin

-

Hematuria

Yes

10

Dal

1995

31

F

-

Yes

ASD clousure

Harvey 1700 model bubble oxygenator

Plasma, priming fluid, mannitol

34

-

7

35

Minimal

-

-

10

No

No

11

Yamagishi

1998

50

M

-

No

AVR (mech 23 mm)

-

Crystalloid solution

-

-

-

-

800

RBC, FFP (autologus)

Cell saver, ferrous supplementation, rHuEPO

-

No

No

12

Aoyagi

2001

9

F

HSM

Yes

ASD closure

-

Ringer’s solution, mannitol, albumins, hydroxyethylated starch

Normothermic

-

-

30

-

RBC (autologus)

Haptoglobin

14

-

-

13

Walther

2005

6 weeks

-

CM

No

OPCAB

OPCAB

-

-

-

-

-

-

-

-

15

No

-

14

Yoshimura

2006

18 months

F

-

No

VSD closure, PV commissurotomy,

PT patch angioplasty

Roller pump

Packed RBCs, albumin

-

-

-

150

-

RBC

Haptoglobin, dilutional ultrafiltration

15

No

No

15

Johnson

2010

6

M

DCM

No

HTX

-

Exchange transfusion of packed RBCs, FFP

-

-

-

-

-

RBC, FFP

Exchange transfusion, aprotinin, ultrafiltration

 > 27

Transient neurological complications, CNS hematomas

No

16

Khatri

2010

61

M

IHD, HT, DL

Yes

CABG

-

-

Mild hypothermia, topical ice

Cold, antegrade and retrograde

-

105

-

NO

-

4

No

No

17

Imantalab

2011

60

M

-

Yes

CABG

Medtronic affinity

-

32, topical ice

Cold, antegrade

48

135

-

RBC

Furosemide, NaHCO3, mannitol, ultrafiltration

8

Hematuria, IABP

Yes

18

Spegar

2015

69

M

HT, DL, CVA, AS

Yes

CABG

Roller pump

Non-coated, Quadrox oxygenator

Ringer’s solution, mannitol

Normothermia

Cold, antegrade

-

60

-

RBC (autologus)

-

7

No

No

19

Hargrave

2015

28

F

-

No

VSD closure,

myectomy,

AVR (bio 21 mm),

ascending aortoplasty

-

Retrograde autologous priming

34.8–36.6

Normothermic

50

60

-

RBC

Cell saver

7

-

Yes

20

Matsuzaki

2016

63

M

Endocarditis 10 years ago

No

AVR (bio 21 mm)

AscAO

Centrifuge

-

Moderate hypothermia

Cold, antegrade and retrograde (Frem’s)

182

234

Minimal

RBC

Haptoglobin

18

No

No

21

Huenges

2017

15

F

Premature birth

-

HVAD, HeartWare (transplant 6 weeks after)

-

-

-

-

-

-

-

NO

-

-

RV failure, prolonged mechanical ventilation. Death 2 weeks after HTX

No

22

Menon

2020

7 months

F

Down syndrome

No

VSD closure

MVpl

ASD closure

Roller pump

Packed RBCs, albumin

Mild hypothermia

-

89

121

-

RBC, FFP

Ultrafiltration

6

No

No

23

Stevens

2021

19 months

F

-

No

AVSD closure

Roller pump

Exchange transfusion of RBCs and FFP

mild hypothermia

Cold, antegrade (del Nido)

35

57

-

RBC, FFP, PLT

Exchange transfusion

4

No

No

  1. AS atherosclerosis, ASD autism spectrum disorder, AVR aortic valve replacement, AVSD atrioventricular septal defect, Bio bioprosthesis, CABG coronary artery bypass graft surgery, CM cardiac malformation, CNS central nervous system, CPB cardiopulmonary bypass, CVA cerebrovascular accident, DCM dilated cardiomyopathy, DL dyslipidemia, F female, FFP fresh-frozen plasma, HF heart failure, HSM hepatosplenomegaly, HT arterial hypertension, HTX heart transplantation, HVAD HeartWare ventricular assist device, IABP intra-aortic balloon pump, IHD ischemic heart disease, LA left atrium, LOS length of hospital stay, M male, Mech mechanical prothesis, MVpl mitral valve valvuloplasty, MVR mitral valve replacement, OPCAB off-pump coronary artery bypass, PDA patent ductus arteriosus, PLT platelets, PT pulmonary trunk, PV pulmonic valve, RBC red blood cells, rHuEPO recombinant human erythropoietin, RV right ventricle, TVR tricuspid valve replacement, VSD ventricular septal defect