Table 1 Univariable analyses of risk and prognostic baseline factors

Age

 < 50

71 (2.0%)

0 (0.0%)

71 (2.2%)

-

-

0 (0.0%)

71 (2.7%)

-

-

 60–70 (ref.)

121 (3.4%)

1 (0.3%)

120 (3.7%)

-

-

4 (0.4%)

117 (4.5%)

-

-

 61–70

335 (9.5%)

10 (3.3%)

325 (10.1%)

3.69 (0.47 – 29.15)

0.215

37 (4.1%)

298 (11.4%)

3.63 (1.27 – 10.41)

0.016

 71–80

825 (23.4%)

48 (15.9%)

777 (24.1%)

7.41 (1.01 – 54.21)

0.048

151 (16.6%)

674 (25.8%)

6.55 (2.38 – 18.03)

 < 0.001

 81–90

1519 (43.1%)

137 (45.4%)

1382 (42.9%)

11.90 (1.65 – 85.81)

0.014

438 (48.1%)

1081 (41.4%)

11.85 (4.35 – 32.30)

 < 0.001

 > 91

652 (18.5%)

106 (35.1%)

546 (17.0%)

23.30 (3.22 – 168.58)

0.002

281 (30.8%)

371 (14.2%)

22.15 (8.08 – 60.74)

 < 0.001

Variables of the CCI

 AIDS

4 (0.1%)

1 (0.3%)

3 (0.1%)

1.24 (0.85 – 1.80)

0.272

1 (0.1%)

3 (0.1%)

0.99 (0.68 – 1.45)

0.969

 Cerebrovascular disease

721 (20.5%)

73 (24.2%)

648 (20.1%)

1.27 (0.96 – 1.67)

0.096

235 (25.8%)

486 (18.6%)

1.52 (1.27 – 1.82)

 < 0.001

 Chronic pulmonal disease

316 (9.0%)

34 (11.3%)

282 (8.8%)

1.32 (0.91 – 1.93)

0.147

93 (10.2%)

223 (8.5%)

1.22 (0.94 – 1.57)

0.129

 Congestive heart failure

675 (19.2%)

77 (25.5%)

598 (18.6%)

1.50 (1.14 – 1.97)

0.004

231 (25.4%)

444 (17.0%)

1.66 (1.38 – 1.99)

 < 0.001

 Connective tissue disease

156 (4.4%)

9 (3.0%)

147 (4.6%)

0.64 (0.32 – 1.27)

0.204

33 (3.6%)

123 (4.7%)

0.76 (0.51 – 1.13)

0.171

 Dementia

804 (22.8%)

137 (45.4%)

667 (20.7%)

3.18 (2.50 – 4.05)

 < 0.001

354 (38.9%)

450 (17.2%)

3.05 (2.58 – 3.61)

 < 0.001

 Diabetes

644 (18.3%)

71 (23.5%)

573 (17.8%)

1.42 (1.07 – 1.88)

0.014

219 (24.0%)

425 (16.3%)

1.63 (1.35 – 1.96)

 < 0.001

 Diabetes with end organ damage

0 (0.0%)

-

-

-

-

-

-

-

-

 Hemiplegia

121 (3.4%)

11 (3.6%)

110 (3.4%)

1.03 (0.75 – 1.42)

0.836

40 (4.4%)

81 (3.1%)

1.20 (0.99 – 1.45)

0.067

 Leukemia

14 (0.4%)

1 (0.3%)

13 (0.4%)

0.91 (0.33 – 2.51)

0.848

7 (0.8%)

7 (0.3%)

1.70 (1.00 – 2.87)

0.048

Liver disease

 Mild

10 (0.3%)

1 (0.3%)

9 (0.3%)

1.19 (0.15 – 9.39)

0.872

2 (0.2%)

8 (0.3%)

0.72 (0.15 – 3.38)

0.674

 Moderate or severe

13 (0.4%)

1 (0.3%)

12 (0.4%)

0.89 (0.12 – 6.86)

0.910

4 (0.4%)

9 (0.3%)

1.27 (0.39 – 4.15)

0.687

 Lymphoma

25 (0.7%)

0 (0.0%)

25 (0.8%)

-

-

4 (0.4%)

21 (0.8%)

0.74 (0.43 – 1.26)

0.266

 Moderate or severe renal disease

59 (1.7%)

9 (3.0%)

50 (1.6%)

1.40 (0.97 – 2.00)

0.069

23 (2.5%)

36 (1.4%)

1.36 (1.05 – 1.77)

0.022

 Myocardial infarction

320 (9%)

37 (12.3%)

283 (8.8%)

1.45 (1.01 – 2.09)

0.046

109 (12.0%)

211 (8.1%)

1.55 (1.21 – 1.98)

 < 0.001

 Peptic ulcer disease

3 (0.1%)

1 (0.3%)

2 (0.1%)

5.35 (0.48 – 59.14)

0.172

1 (0.1%)

2 (0.1%)

1.43 (0.13 – 15.8)

0.769

 Peripheral vascular disease

122 (3.5%)

13 (4.3%)

109 (3.4%)

1.28 (0.71 – 2.31)

0.404

36 (4.0%)

86 (3.3%)

1.21 (0.81 – 1.80)

0.349

Tumor

 Local

412 (11.7%)

38 (12.6%)

374 (11.6%)

1.09 (0.77 – 1.56)

0.621

16 (1.8%)

266 (10.2%)

1.70 (1.36 – 2.11)

 < 0.001

 Metastatic

16 (0.5%)

1 (0.3%)

15 (0.5%)

0.72 (0.09 – 5.46)

0.749

8 (0.9%)

8 (0.3%)

3.09 (1.16 – 8.26)

0.025

Original CCI (mean ± SD)

5.05 (± 1.99)

6.05 (± 1.61)

4.95 (± 2.00)

1.30 (1.23 – 1.38)

 < 0.001

6.05 (± 1.69)

4.70 (± 1.97)

1.45 (1.39 – 1.51)

 < 0.001

Adjusted CCI (mean ± SD)

4.64 (± 1.85)

5.76 (± 1.61)

4.54 (± 1.84)

1.42 (1.33 – 1.51)

 < 0.001

5.65 (± 1.59)

4.29 (± 1.81)

1.55 (1.48 – 1.63)

 < 0.001