Preoperative neutrophil–to–lymphocyte ratio after chemoradiotherapy for esophageal squamous cell carcinoma associates with postoperative pulmonary complications following radical esophagectomy

Table 5 Results of univariate log-rank analysis of prognostic factors for overall survival and disease-free survival in 111 patients with stage III esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy followed by esophagectomy

Factors	No. of patients	Overall survival (OS)		Disease-free survival (DFS)
Factors	No. of patients	3-year OS rate (%)	P-value	3-year DFS rate (%)	P-value
Age, years
< 52	51	49	0.88	41	0.96
≥ 52	60	48		40
Clinical 7th AJCC stage
IIIA/IIIB	41	66	0.039*	54	0.04*
IIIC	70	39		33
Clinical T classification
T2/3	50	66	0.011*	54	0.01*
T4	61	34		30
Clinical N classification
N0/1	51	53	0.87	39	0.97
N2/3	60	45		42
Tumor grade
Grade 1/2	86	51	0.26	41	0.30
Grade 3	25	40		40
Primary tumor location
Upper	26	46	0.59	42	0.69
Middle/Lower	85	49		40
Primary tumor location
Upper/Middle	75	48	0.34	43	0.29
Lower	36	50		36
NLR
< 3	46	70	0.0026*	57	0.0055*
≥ 3	65	34		29
PLR
< 140	35	63	0.396	46	0.53
≥ 140	76	42		38
Pathological CR
Absent	73	40	0.0018*	27	0.0011*
Present	38	69		66
Surgical complications
Absent	36	55	0.12	47	0.13
Present	75	44		36
Pulmonary complications
Absent	79	59	< 0.0001*	49	< 0.0001*
Present	32	20		17

NLR neutrophil-to-lymphocyte ratio, PLR platelet-to- lymphocyte ratio, CR complete response
^*Statistically significant

ISSN: 2047-0525