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Table 4 Analgesic regimens

From: A systematic review and meta-analysis of thoracic epidural analgesia versus other analgesic techniques in patients post-oesophagectomy

Year and author

Analgesic modality

N

Analgesic location

Drug regimen

Additional analgesia

Flisberg et al. 2001

TEA

18

T6–12

4 ml/h 0.25% bupivacaine + 0.125 mg/ml morphine

4–6 ml 0.25% bupivacaine clinician bolus + / − clinician SC morphine

IV

15

 

0.5–4 mg/h IV morphine

0.5–2 mg IV PCA morphine/15-min lockout + /– clinician SC morphine

Yokoyama et al. 2005

Bilevel TEA

15

T34 + T10–11

4 ml/h 0.2% ropivacaine + 4 mcg/ml fentanyl

5-ml 0.2% ropivacaine clinician bolus

IV

15

 

1 mg/h morphine IV

2.5-mg IV PCA bolusa

Fares et al. 2014

TEA

15

T5–7

0.1 ml/kg/h 0.125% bupivacaine + 5 mcg/ml fentanyl

1-mg IV PCA morphine/5-min lockout

IV

15

 

1-mg morphine IV PCA/5-min lockout

NR

Liu and Wang 2015

TEA

30

T7–8

4-ml load + 4 ml/h of 0.1% ropivacaine

4-ml PCEA bolus/40-min lockout

IV

30

 

5-ml load + 1 ml/h IV of 80-ml normal saline with 800-mg tramadol + 100-mg flurbiprofen

2-ml IV PCA bolus/15-min lockout

Wang et al. 2017

TEA

40

T7–8

3–4 ml/h 0.125% bupivacaine + 20 mcg/ml morphine

3–4 ml PCEA bolusa

IV

40

 

0.6–1 mg/h morphine

2–3 mg IV PCA bolusa

Wang et al. 2017

TEA

20

NR

3 ml/h 0.125% ropivacaine + 0.4 mcg/ml sufentanil

3 ml/15-min lockout PCEA bolus

IV

20

 

0.03 mcg/kg/h sufentanil + 0.5 mg/ml flurbiprofen at 3 ml/h

3-ml PCA bolus/15-min lockout (sufentanil + flurbiprofen)

Li 2019

TEA

50

T7–8

0.125% ropivacaine + 2 mcg/ml fentanyl at 5 ml/h

2-ml PCEA bolus/15-min lockout

IV

50

 

6 mcg/kg fentanyl + 12 mg/kg tramadol in 100 ml at 2 ml/h

2-ml IV PCA bolus/15-min lockout

Zhu et al. 2020

TEA

60

T4–6

2 ml/h of 100-ml normal saline with 200–300 mcg fentanyl, 150-mg ropivacaine and 5-mg droperidol

0.5-ml PCEA bolus/15-min lockout

IV

60

 

2 ml/h of 100-ml normal saline with 15 mcg/kg fentanyl

2-ml IV PCA bolus/15-min lockout

Maghsoudloo et al. 2023

TEA

40

T6–8

4 ml/h 0.125% bupivacaine + 1 ml/h PCEA up to max 2 ml/h

3-mg IV PCA morphine bolusa

IV

40

 

10 mcg/kg/h morphine + ketorolac 120 mg/day

3-mg IV PCA morphine bolusa

Xu et al. 2023

TEA

56

T6–9

2 ml/h 0.15% ropivacaine + 0.12 mg/kg morphine in 100 ml

4-ml PCEA bolus/60-min lockout

IV

56

 

1 mg/h IV PCA oxycodone

2-mg IV PCA bolus/5-min lockout

PVB + TAP

56

T4–7

PVB 15-ml 0.33% ropivacaine at each level. TAP 20-ml 0.25% ropivacaine. Both intraoperative single-shot blocks

1 mg/h IV oxycodone + 2-mg IV PCA bolus 5-min lockout

  1. N number, IV intravenous, TEA thoracic epidural analgesia, PCA patient-controlled analgesia, PCEA patient-controlled epidural analgesia, SC subcutaneous, PVB paravertebral block, TAP transversus abdominis plane block. aNo lockout time reported