Outcomes | No. of participants (studies) Follow-up | Certainty of the evidence (GRADE) | Relative effect (95% CI) | Anticipated absolute effects | |
---|---|---|---|---|---|
Risk with control | Risk difference with GLP-1RA | ||||
Preoperative gastrointestinal symptoms | 762 (3 RCTs) | ⨁⨁⨁⨁ Higha | OR 7.66 (3.42 to 17.70) | 32 per 1000 | 172 more per 1000 (70 more to 340 more) |
Insulin rescue administration | 629 (5 RCTs) | ⨁⨁⨁⨁ High | OR 0.39 (0.23 to 0.68) | 612 per 1000 | 231 fewer per 1000 (346 fewer to 94 fewer) |
Glycemic level | 590 (6 RCTs) | ⨁⨁⨁⨁ High | - | MD 0.73 lower (1.13 lower to 0.33 lower) | |
Hypoglycemic events | 680 (7 RCTs) | ⨁⨁⨁◯ Moderateb | OR 0.60 (0.29 to 1.24) | 74 per 1000 | 28 fewer per 1000 (51 fewer to 16 more) |
Hyperglycemic events | 435 (3 RCTs) | ⨁⨁⨁⨁ High | OR 0.89 (0.59 to 1.34) | 347 per 1000 | 26 fewer per 1000 (108 fewer to 69 more) |
Postoperative inotropic support assessed with the following: use of dobutamine, milrinone, and epinephrine | 453 (5 RCTs) | ⨁⨁⨁◯ Moderateb | OR 0.57 (0.33 to 1.01) | 173 per 1000 | 67 fewer per 1000 (109 fewer to 1 more) |
Postoperative nausea/vomiting (PONV) | 572 (5 RCTs) | ⨁⨁⨁◯ Moderateb | OR 1.35 (0.82 to 2.21) | 125 per 1000 | 37 more per 1000 (20 fewer to 115 more) |
Postoperative atrial fibrillation (A fib) | 465 (5 RCTs) | ⨁⨁⨁◯ Moderateb | OR 1.02 (0.52 to 2.01) | 124 per 1000 | 2 more per 1000 (56 fewer to 98 more) |
30-day postoperative mortality rate | 482 (4 RCTs) | ⨁⨁⨁◯ Moderateb | OR 0.54 (0.14 to 2.05) | 24 per 1000 | 11 fewer per 1000 (21 fewer to 24 more) |
Residual gastric content assessed with endoscopy | 991 (3 nonrandomized studies) | ⨁⨁⨁⨁ Highc | OR 6.08 (2.86 to 12.94) | 33 per 1000 | 139 more per 1000 (56 more to 274 more) |