Changes of perioperative cognitive function and its effect on quality of life in laryngeal cancer

Table 3 Statistical analysis of factors influencing cognitive function in patients with laryngeal squamous cell carcinoma before and after surgery

Entry	Preoperative cognitive function				Postoperative cognitive function
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	T (95%CI)	p	OR (95%CI)	p	T (95%CI)	p	OR (95%CI)	p
Age (Y)	− 4.570 (− 9.033 to − 3.557)	< 0.001*	1.156 (1.049–1.274)	0.003*	− 5.250 (− 9.631 to − 4.340)	< 0.001*	1.269 (1.033–1.560)	0.023*
Anxiety	− 3.652 (− 11.405 to − 3.360)	< 0.001*	1.073 (1.013–1.137)	0.016*	− 5.890 (− 14.330 to − 7.098)	< 0.001*	1.204 (1.007–1.438)	0.041*
Depression	− 2.067 (− 7.329 to − 0.136)	0.042*	1.047(0.981–1.117)	0.169	− 0.940 (− 4.948–1.772)	0.350	–	–
Marital status	− 2.067 (− 7.329 to − 0.136)	0.920	–	–	− 1.164 (− 0.517–0.135)	0.247	–	–
Cancer stage	− 1.604 (− 0.383–0.041)	0.113	–	–	− 3.229 (− 0.529 to − 0.126)	0.002*	0.238 (0.021–2.746)	0.250
Education level	2.274 (0.027–0.400)	0.025*	0.351 (0.097–1.269)	0.110	1.351 (–0.061–0.318)	0.180	–	–
Operative method	0.534 (0.000–0.076)	0.467	–	–	− 6.242 (− 0.854 to − 0.441)	< 0.001*	0.000(0.000–0.988)^a	0.050*
Operative method	0.534 (0.000–0.076)	0.467	–	–	− 6.242 (− 0.854 to − 0.441)	< 0.001*	0.022(0.001–0.491)^a	0.016*
Preoperative MoCA score	–	–	–	–	6.395 (1.738–3.305)	< 0.001*	0.500 (0.299–0.834)	0.008*

T student t test, OR odds ratio, CI confidence interval, MoCA Montreal Cognitive Assessment
^aThe operation modes included minimally invasive laser surgery, partial laryngectomy, and total laryngectomy, thus, in the analysis of postoperative cognitive function of the operation modes, the three methods were stratified and pairwise analysis was proceeded
^*p < 0.05

ISSN: 2047-0525