Table 3 Mediated effects by total volume infused on the associations of NT-proBNP levels with AKI (n = 629)

Mediation: Total volume infused

Total effects (95% CI)

3.22 × 10⁻⁵ (9.62 × 10⁻⁶ to5.43 × 10⁻⁵)

0.004

Direct effects (95% CI)

2.71 × 10⁻⁵ (6.14 × 10⁻⁶ to 4.87 × 10⁻⁵)

0.010

Mediated effects (95% CI)

5.13 × 10⁻⁶ (2.53 × 10⁻⁷ to 1.10 × 10⁻⁵)

0.040

Proportion mediated by total volume infused 15.5%